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<t>Radio-HPLC-chromatograms</t> of the purified radioiodinated radioligands mcp-M-[ 123 I]­alb-PSMA with t R = 11.5 min (A) and mcp-D-[ 123 I]­alb-PSMA with t R = 12.2 min (B).
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<t>Radio-HPLC-chromatograms</t> of the purified radioiodinated radioligands mcp-M-[ 123 I]­alb-PSMA with t R = 11.5 min (A) and mcp-D-[ 123 I]­alb-PSMA with t R = 12.2 min (B).
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<t>Radio-HPLC-chromatograms</t> of the purified radioiodinated radioligands mcp-M-[ 123 I]­alb-PSMA with t R = 11.5 min (A) and mcp-D-[ 123 I]­alb-PSMA with t R = 12.2 min (B).
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<t>Radio-HPLC-chromatograms</t> of the purified radioiodinated radioligands mcp-M-[ 123 I]­alb-PSMA with t R = 11.5 min (A) and mcp-D-[ 123 I]­alb-PSMA with t R = 12.2 min (B).
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<t>Radio-HPLC-chromatograms</t> of the purified radioiodinated radioligands mcp-M-[ 123 I]­alb-PSMA with t R = 11.5 min (A) and mcp-D-[ 123 I]­alb-PSMA with t R = 12.2 min (B).
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<t>Radio-HPLC-chromatograms</t> of the purified radioiodinated radioligands mcp-M-[ 123 I]­alb-PSMA with t R = 11.5 min (A) and mcp-D-[ 123 I]­alb-PSMA with t R = 12.2 min (B).
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Radio-HPLC-chromatograms of the purified radioiodinated radioligands mcp-M-[ 123 I]­alb-PSMA with t R = 11.5 min (A) and mcp-D-[ 123 I]­alb-PSMA with t R = 12.2 min (B).

Journal: Journal of Medicinal Chemistry

Article Title: Diagnostic Twins: Exploring the Radiohybrid Concept with Iodine-123 and Lanthanum-133 for PSMA-Targeted SPECT and PET Imaging

doi: 10.1021/acs.jmedchem.6c00161

Figure Lengend Snippet: Radio-HPLC-chromatograms of the purified radioiodinated radioligands mcp-M-[ 123 I]­alb-PSMA with t R = 11.5 min (A) and mcp-D-[ 123 I]­alb-PSMA with t R = 12.2 min (B).

Article Snippet: Purification of the 123 I-ligands was performed by semipreparative radio-HPLC: Jasco LC-NetII/ADC HPLC system with a GABI gamma spectrometer (Elysia-Raytest GmbH) with a Phenomenex Luna C18 column (10 μm, 250 × 10 mm) using a linear gradient from H 2 O/acetonitrile +0.1% TFA: 75/25 → 25/75 in 33 min, flow rate: 4 mL/min.

Techniques: Purification

Radio-HPLC-chromatograms of [ 133 La]­La-mcp-M-alb-PSMA with t R = 14.9 min (A) and [ 133 La]­La-mcp-D-alb-PSMA with t R = 17.5 min (B); free [ 133 La]­La 3+ appears at t R = 2.5 min.

Journal: Journal of Medicinal Chemistry

Article Title: Diagnostic Twins: Exploring the Radiohybrid Concept with Iodine-123 and Lanthanum-133 for PSMA-Targeted SPECT and PET Imaging

doi: 10.1021/acs.jmedchem.6c00161

Figure Lengend Snippet: Radio-HPLC-chromatograms of [ 133 La]­La-mcp-M-alb-PSMA with t R = 14.9 min (A) and [ 133 La]­La-mcp-D-alb-PSMA with t R = 17.5 min (B); free [ 133 La]­La 3+ appears at t R = 2.5 min.

Article Snippet: Purification of the 123 I-ligands was performed by semipreparative radio-HPLC: Jasco LC-NetII/ADC HPLC system with a GABI gamma spectrometer (Elysia-Raytest GmbH) with a Phenomenex Luna C18 column (10 μm, 250 × 10 mm) using a linear gradient from H 2 O/acetonitrile +0.1% TFA: 75/25 → 25/75 in 33 min, flow rate: 4 mL/min.

Techniques:

Stability determination of [ 133 La]­La-mcp-M-alb-PSMA human serum after incubation at 37 °C. Samples were taken after 1, 4, and 24 h and analyzed by radio-HPLC.

Journal: Journal of Medicinal Chemistry

Article Title: Diagnostic Twins: Exploring the Radiohybrid Concept with Iodine-123 and Lanthanum-133 for PSMA-Targeted SPECT and PET Imaging

doi: 10.1021/acs.jmedchem.6c00161

Figure Lengend Snippet: Stability determination of [ 133 La]­La-mcp-M-alb-PSMA human serum after incubation at 37 °C. Samples were taken after 1, 4, and 24 h and analyzed by radio-HPLC.

Article Snippet: Purification of the 123 I-ligands was performed by semipreparative radio-HPLC: Jasco LC-NetII/ADC HPLC system with a GABI gamma spectrometer (Elysia-Raytest GmbH) with a Phenomenex Luna C18 column (10 μm, 250 × 10 mm) using a linear gradient from H 2 O/acetonitrile +0.1% TFA: 75/25 → 25/75 in 33 min, flow rate: 4 mL/min.

Techniques: Incubation